- Australian Labradoodle
- Great Dane
- Labrador Retriever
Centronuclear Myopathy (CNM) in Labrador Retrievers is a recessively inherited muscular disease. This disease was previously known as Labrador muscular myopathy. The disease is characterized by early onset muscular problems such as awkward gait, fatigue, and difficulty eating. Affected puppies generally begin displaying these problems within a few months after birth.
Researchers in France, Drs. Tiret and Blot at The Alfort School of Veterinary Medicine discovered the mutation that is responsible for the disease. The test offered here is based on this discovery. This is not the same as Exercise Induced Collapse (EIC).
As with other recessive diseases, animals with two copies of the mutation will be affected and display symptoms, whereas animals with one copy (carriers) and no copies (clear) will be symptom free.
In Great Dane the disease manifests itself very much like the Labrador Retriever CNM, but the disease is caused by a different mutation in a different gene.
The dog has 2 copies of the normal gene and will neither develop CNM,
The dog has one copy of the normal gene and one copy of the mutant gene that causes CNM.
The dog has two copies of the CNM mutation and is affected with CNM.
Carriers can still be bred to clear dogs. On average, 50% of such a litter will be clear and 50% carriers; there can be no affected puppies produced from such a mating. Dogs which will be used for breeding can themselves be DNA tested to determine whether they are clear or carrier.