- Great Danes
GDV- Gastric Dilatation Volvulus/Bloat
This condition is a problem in most large dog breeds, but especially so in Great Danes. In this breed it has been suggested that up to 37% of adult dogs will experience an incident at some point in their lives, and the condition may be life threatening if not treated immediately. Researchers at the Fred Hutchinson Cancer Research Center have identified three risk alleles in three different genes associated with GDV in Great Danes. Each of them alone increases the odds of a GDV event by at least twofold. Vetgen has licensed the test for these risk alleles and may now offer it to the Great Dane community.
The test identifies seven mutations in three different genes which permits identification of the “risk alleles,” which are not causative of GDV but are highly associated.
Results for this test will not come in the form of clear, carrier and affected as they do for direct causative mutations, but rather:
0 copies, 1 copy, or 2 copies for RISK ALLELE 1
0 copies, 1 copy, or 2 copies for RISK ALLELE 2
0 copies, 1 copy, or 2 copies for RISK ALLELE 3