- Australian Labradoodle
- Labrador Retriever
Myotubular Myopathy, X-linked
Myotubular Myopathy, X-linked, is a very rare sex-linked condition with symptoms similar to centronuclear myopathy (CNM). It is found in male Labrador retriever dogs and characterized by progressive skeletal muscle atrophy beginning shortly after birth, causing short strides and slow movement compared to littermates and eventually fatally impairing the dog’s gait. Although the mode of inheritance is recessive, male dogs born from a carrier female require just one copy of the mutation, the other gene linked to the X chromosome from which disease gets its name. Therefore, the disease is limited primarily to male dogs due to the sex-linked mode of inheritance.
Unlike the original CNM mutation which is seen worldwide at a high frequency this disease appears to be very recent in origin and therefore isolated and rare. The only affected animals we know of are from western Canada.
Result types: Males- Clear or Affected
Females- Clear, Carrier, Affected