- Alaskan Malamute
- Alaskan Husky
- Black Russian Terrier
The polyneuropathies are a collection of diseases that affect the peripheral nervous system. Most of these are inherited as autosomal recessive traits that resemble Charcot-Marie-Tooth Syndrome (CMT) in humans. Affected dogs may exhibit generalized weakness, an abnormal gait, and muscle atrophy primarily of the hind limbs. The tests that have been developed have been for early onset forms of the disease, although both early and late onset forms are known to exist, particularly in the Leonberger.
The polyneuropathies detected in the Alaskan Husky and Black Russian Terrier are somewhat different from the others in that they also have ocular abnormalities and more closely resembles the human Warburg Microsyndrome (WARBM).
Inheritance: autosomal recessive