VetGen - The leader in veterinary genetic disease research and genetic disease detection services for purebred animals

Breeding Strategies

VetGen's DNA test findings can be extremely valuable when developing and implementing your breeding plans.

Interpreting your DNA test results for autosomal dominant diseases

There are only two possible test results for autosomal dominant diseases, affected or clear.

Affected

This finding indicates that either one or two copies of the disease causing mutation are present. While the animal may or may not be exhibiting signs of the disease, it should not be used in any breeding program.

Clear

This finding means that no copies of the disease causing mutation are present and the animal will not be affected by the disease and is safe to use in a breeding program.

The only acceptable BREEDING STRATEGY for an autosomal dominant disease is CLEAR to CLEAR.

Helpful Feline Breeding Chart

Clear Male Affected Male
(1 copy)
Affected Male
1 copies)
Clear Female 100% Clear 50%clear/50% affected 100% affected
Affected Female
(1 copy)
50%clear/50% affected 25% clear/75% affected 100% affected
Affected Female
(2 copies)
100% affected 100% Affected 100% affected

Ideal Breeding Pair - Kittens will not have the disease gene.

High Risk Breeding - 50% affected and 50% clear

Breeding Not Recommended - All kittens will be genetically and medically affected

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