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CMO- Craniomandibular Osteopathy

CMO is a bone disease that affects young dogs in several breeds, but most notably West Highland White and Scottish.Terriers. Affected dogs may exhibit a variety of symptoms including pain, periodic fever, difficulty opening the mouth and growth of bony lesions primarily on cranial bones. In 2015, researchers at the University of Bern and the University of Helsinki described a mutation associated with this disease in three terrier breeds. The disease appears to be inherited as an autosomal dominant mutation with incomplete penetrance. Most affected animals have two copies of the mutation but some have only a single copy. This appears to be somewhat breed dependent as all of the Scottish and Cairn Terriers that had two copies were diagnosed with CMO. In West Highland Whites, where the mutation is most common (40% have one copy), about half of the dogs with two copies were diagnosed with CMO. Scotties and Westies with one copy were diagnosed with CMO at rates of 7% and 3.5%, respectively.

Result types:

Zero Copies of the mutation
One copy of the mutation
Two copies of the mutation

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